Investigating how DNA in cells causes inflammation and aging
Role of cytosolic DNA-induced sterile inflammation driving cellular and organismal progeria/aging hallmarks
This study is looking at how certain DNA in our cells can cause inflammation that speeds up aging and related diseases, especially in kids with Hutchinson-Gilford Progeria Syndrome, to find new ways to help improve their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10901042 on NIH RePORTER |
What this research studies
This research explores the role of cytosolic DNA in triggering inflammation that contributes to aging and related diseases, particularly focusing on Hutchinson-Gilford Progeria Syndrome (HGPS). The study aims to understand the mechanisms behind the accumulation of cytosolic DNA and its effects on cellular health and tissue deterioration. By examining the roles of specific proteins involved in inflammation, the researchers hope to identify potential therapeutic targets that could improve health outcomes for individuals with progeria and possibly other aging-related conditions. The approach includes both laboratory experiments and animal models to validate findings.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Hutchinson-Gilford Progeria Syndrome or those experiencing accelerated aging symptoms.
Not a fit: Patients with typical aging processes or those without genetic predispositions to accelerated aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve health and longevity in patients with progeria and potentially other age-related diseases.
How similar studies have performed: Previous research has shown promising results in targeting inflammation pathways to improve healthspan and lifespan in animal models, suggesting potential for success in this approach.
Where this research is happening
Saint Louis, United States
- Saint Louis University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Gonzalo Hervas, Susana — Saint Louis University
- Study coordinator: Gonzalo Hervas, Susana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.