Investigating how DNA damage and repair processes relate to opioid addiction
The role of DNA breaks and repairs in opioid addiction
['FUNDING_OTHER'] · UNIVERSITY OF KANSAS LAWRENCE · NIH-10896436
This study is looking at how damage to DNA in the brain might affect addiction to opioids, with the goal of understanding why people often relapse, so it can help those struggling with opioid use disorder.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS LAWRENCE (nih funded) |
| Locations | 1 site (LAWRENCE, UNITED STATES) |
| Trial ID | NIH-10896436 on ClinicalTrials.gov |
What this research studies
This research explores the connection between DNA breaks and repairs and opioid addiction, focusing on how these processes affect gene expression in the brain. By examining postmortem brain tissues and using animal models, the study aims to understand the role of DNA damage in the neuroplastic changes that contribute to opioid use disorder. The researchers will utilize advanced techniques, including CRISPR, to investigate how alterations in DNA can influence behaviors associated with addiction. This work seeks to uncover the underlying mechanisms that lead to the high rates of relapse in individuals with opioid addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of opioid use disorder who may benefit from innovative treatment approaches.
Not a fit: Patients who are not affected by opioid addiction or those who have not engaged in opioid use may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that target the molecular mechanisms of opioid addiction, potentially reducing relapse rates.
How similar studies have performed: While the specific approach of linking DNA damage to opioid addiction is novel, related research has shown promising results in understanding the genetic and epigenetic factors involved in addiction.
Where this research is happening
LAWRENCE, UNITED STATES
- UNIVERSITY OF KANSAS LAWRENCE — LAWRENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, ZIJUN — UNIVERSITY OF KANSAS LAWRENCE
- Study coordinator: WANG, ZIJUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.