Investigating how DNA damage affects brain function and health
Role of DNA double-strand breaks in neural function and homeostasis
This study is looking at how breaks in DNA in our brain cells might affect our thinking and memory as we get older, and it hopes to find new ways to help keep our brains healthy as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10843769 on NIH RePORTER |
What this research studies
This research explores the role of DNA double-strand breaks in the brain and how they may contribute to cognitive decline and neurodegenerative disorders as we age. By studying the mechanisms of DNA repair in neurons, the research aims to understand how these processes impact brain function and overall neural health. The approach involves examining the relationship between DNA repair pathways and neural circuit function, which could lead to new therapeutic strategies for age-related brain disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or those at risk for neurodegenerative disorders.
Not a fit: Patients with acute brain injuries or those with non-age-related cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and prevent neurodegenerative diseases in aging populations.
How similar studies have performed: Previous research has shown that DNA repair mechanisms are crucial for maintaining brain health, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Schwer, Bjoern — University of California, San Francisco
- Study coordinator: Schwer, Bjoern
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.