Investigating how DNA damage affects aging and repair mechanisms
Official title: Core D: DNA Damage Signaling and Repair
Funded at University of Minnesota · NIH-11117550 · Data updated 2026-11-12
This study is looking at how our bodies handle DNA damage as we get older, using special tools to learn more about how this affects aging and our ability to heal, with the goal of helping older adults stay healthier.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | June 17, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $254,100 |
| NIH project number | 1P30AG092751-01 |
| Project ID | NIH-11117550 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are older adults experiencing age-related health issues or those with conditions linked to DNA damage.
✕Less likely to help
Patients with acute, non-age-related conditions or those who are not elderly may not receive benefits from this research.
What this research studies
This research focuses on understanding the processes involved in DNA damage and repair as they relate to aging. It utilizes advanced techniques such as cytometry by time of flight (CyTOF) and functional assays to assess the proteins and activities involved in the DNA damage response and cellular senescence. By providing researchers with innovative tools and reagents, the project aims to deepen our understanding of how DNA damage impacts aging and the body's ability to repair itself. This work is part of a larger initiative to explore the biology of aging and improve health outcomes for older adults.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing age-related diseases and enhancing the healthspan of older adults.
How similar studies have gone: Other research has shown success in using similar approaches to study DNA damage and aging, indicating a promising avenue for further exploration.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Revelo, Xavier — University of Minnesota
- Study coordinator: Revelo, Xavier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.