Investigating how DNA changes during early embryo development
Understanding DNA methylation reprogramming dynamics during preimplantation development using single-cell sequencing
This study is looking at how DNA changes in the early stages of embryo development, which is important for making sure embryos grow properly, and it could help us understand more about normal development and issues that might arise with assisted reproductive technologies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Barbara NIH-funded |
| Lab location | 1 site (Santa Barbara, United States) |
| Project ID | NIH-10651818 on NIH RePORTER |
What this research studies
This research focuses on understanding the changes in DNA methylation that occur during the early stages of embryo development. By using advanced single-cell sequencing techniques, the study aims to uncover the molecular mechanisms that regulate the erasure of DNA methylation from parental genomes. This process is crucial for resetting the genetic information in gametes and ensuring proper development of the embryo. Insights gained from this research could enhance our understanding of normal embryonic development and the potential causes of disorders related to assisted reproductive technologies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing assisted reproductive technologies or those interested in understanding embryonic development.
Not a fit: Patients who are not seeking fertility treatments or have no interest in reproductive health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes in assisted reproductive technologies and a better understanding of embryonic development disorders.
How similar studies have performed: Previous research has shown promising results in understanding DNA methylation dynamics, indicating that this approach could yield valuable insights.
Where this research is happening
Santa Barbara, United States
- University of California Santa Barbara — Santa Barbara, United States (Active)
Researchers
- Principal investigator: Dey, Siddharth Subhas — University of California Santa Barbara
- Study coordinator: Dey, Siddharth Subhas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.