Investigating how DNA changes during cell division may affect aging.
Progressive DNA Hypomethylation as a Measure of Mitotic History and Potential Contributor to Replicative Senescence.
This study is looking at how changes in DNA during cell division might be linked to aging, using human cells to see if dividing cells lose important DNA markers, and it hopes to create a way to track how this process affects aging over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-10830412 on NIH RePORTER |
What this research studies
This research explores the relationship between DNA methylation changes and cell division, which are believed to contribute to aging. By using primary human cell cultures, the study aims to validate that the process of mitosis leads to a loss of DNA methylation, a key epigenetic marker. The researchers will also examine the mechanisms behind this hypomethylation and its implications for cellular aging. Ultimately, the goal is to develop a molecular clock that reflects mitotic history and its impact on aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in understanding the biological mechanisms of aging and those who may have conditions related to cellular senescence.
Not a fit: Patients with acute conditions unrelated to aging or cellular senescence may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the aging process and potential interventions to promote healthier aging.
How similar studies have performed: While research on DNA methylation and aging is ongoing, this specific approach linking mitotic history to hypomethylation is relatively novel and has not been extensively tested.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Laird, Peter W — Van Andel Research Institute
- Study coordinator: Laird, Peter W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.