Investigating how DNA changes affect brain rhythms in depression
Role of DNA methylation in regulating striatal molecular rhythm alterations in depression
This study is looking at how changes in DNA in the brain might affect mood and behavior in people with depression, especially after experiencing long-term stress, to help us better understand the condition and improve treatment options.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10908512 on NIH RePORTER |
What this research studies
This research explores the role of DNA methylation in altering gene expression rhythms in the brain, particularly in the striatum, which is linked to depression. By analyzing postmortem brain tissue, the study aims to understand how chronic stress influences these DNA changes and disrupts normal brain rhythms. The research employs a multi-omics approach to uncover the mechanisms behind these alterations, potentially leading to new insights into the biological underpinnings of major depressive disorder. Patients may benefit from a deeper understanding of how their condition affects brain function and could inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with major depressive disorder, particularly those experiencing chronic stress.
Not a fit: Patients with depression who do not have chronic stress or those with other psychiatric disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating major depressive disorder by addressing the underlying biological mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding gene expression rhythms in depression, suggesting that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Ketchesin, Kyle — University of Pittsburgh at Pittsburgh
- Study coordinator: Ketchesin, Kyle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.