Investigating how DJ-1 affects energy production and nerve cell health
Role of DJ1 in mitochondrial biogenergetics and neuronal metabolism
This study is looking at how a protein called DJ-1 affects energy production in cells and the health of nerve cells that make dopamine, which is important for people with early-onset Parkinson's disease, to find ways to help improve their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10863845 on NIH RePORTER |
What this research studies
This research explores the role of the DJ-1 protein in energy production within mitochondria and its impact on the health of dopamine-producing nerve cells. By examining how mutations in DJ-1 lead to mitochondrial dysfunction and affect the growth and branching of these neurons, the study aims to uncover the underlying mechanisms of early-onset Parkinson's disease. The approach involves analyzing cellular processes and protein synthesis in both patient-derived cells and animal models to identify potential therapeutic targets. Patients may benefit from insights gained into how to restore normal cellular function and improve neuronal health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with familial Parkinson's disease linked to DJ-1 mutations or those experiencing early-onset symptoms.
Not a fit: Patients with Parkinson's disease not associated with DJ-1 mutations or those with advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance neuronal function and slow the progression of Parkinson's disease.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction in Parkinson's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Jonas, Elizabeth Ann — Yale University
- Study coordinator: Jonas, Elizabeth Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.