Investigating how disrupted polyamine synthesis affects bone loss in chronic kidney disease
Role of disrupted polyamine synthesis during CKD-MBD related bone loss
This study is looking at how problems with certain nutrients might affect bone health in people with chronic kidney disease, using mice to help understand why these patients might have a higher risk of fractures, with the hope of finding better ways to support their bone health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10983317 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between disrupted polyamine synthesis and bone fragility in patients with chronic kidney disease (CKD) and mineral and bone disorder (CKD-MBD). The study utilizes a mouse model to mimic the bone alterations seen in CKD patients, examining how factors like iron deficiency and polyamine levels impact bone health. By analyzing the effects on osteoblast differentiation and function, the research aims to uncover mechanisms that contribute to increased fracture risk in CKD patients. The findings could lead to new insights into managing bone health in individuals with CKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with chronic kidney disease who are experiencing bone health issues or are at risk of fractures.
Not a fit: Patients without chronic kidney disease or those who do not have bone health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing bone loss and fractures in patients with chronic kidney disease.
How similar studies have performed: Previous studies have shown that understanding the role of iron and polyamines in bone health can lead to significant insights, suggesting this research builds on established findings.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Clinkenbeard, Erica L — Indiana University Indianapolis
- Study coordinator: Clinkenbeard, Erica L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.