Investigating how disrupted circadian rhythms affect Alzheimer's disease.
Alzheimer's disease pathogenesis and the desynchronization of cortico-limbic circadian rhythms
This study is looking at how changes in sleep and wake cycles might affect memory and thinking in people with Alzheimer's, using special mouse models to help find new ways to improve brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10827946 on NIH RePORTER |
What this research studies
This research explores the relationship between Alzheimer's disease and the disruption of circadian rhythms in the brain. It aims to understand how these disruptions may contribute to cognitive deficits in individuals with Alzheimer's. Using advanced transgenic mouse models and imaging techniques, the researchers will examine the effects of amyloid beta peptide on circadian timing and its impact on brain function. The goal is to uncover the mechanisms behind cognitive decline in Alzheimer's patients, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with early to mid-stage Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Other research has shown promising results in understanding circadian rhythms in relation to cognitive function, suggesting that this approach may yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Obrietan, Karl H — Ohio State University
- Study coordinator: Obrietan, Karl H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.