Investigating how different types of virus spread affect antibody protection against HIV infection
Assessing if distinct susceptibility to neutralization of cell-free and cell-to-cell spread impacts antibody conferred protection from SHIV infection
This study is looking at how certain antibodies can help stop HIV from spreading, especially for people who can't use current treatments, and it aims to find new ways to protect against the virus by learning from nonhuman primates.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-10589921 on NIH RePORTER |
What this research studies
This research explores how antibodies can prevent HIV infection by examining their effectiveness against both cell-free and cell-to-cell transmission of the virus. It aims to develop new strategies for HIV prevention, particularly for individuals who cannot access current treatments like PrEP due to issues such as drug toxicity or cost. By studying the mechanisms of antibody protection in nonhuman primates, the research seeks to enhance our understanding of how to better utilize antibodies in preventing HIV transmission in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk of HIV acquisition who may not be able to use current prevention strategies like PrEP.
Not a fit: Patients who are already effectively using PrEP or other established HIV prevention methods may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and accessible HIV prevention methods for at-risk populations.
How similar studies have performed: Previous studies have shown promise in using neutralizing antibodies for HIV prevention, indicating that this approach has potential for success.
Where this research is happening
Bethesda, United States
- Henry M. Jackson Fdn for the Adv Mil/med — Bethesda, United States (Active)
Researchers
- Principal investigator: Parsons, Matthew Sidney — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Parsons, Matthew Sidney
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.