Investigating how different types of brain cells affect memory and aging in Alzheimer's disease
Role of Microglial Heterogeneity on Cognitive Resilience in Aging and Alzheimer’s Disease
This study is looking at how special brain cells called microglia help keep our thinking sharp as we get older and deal with Alzheimer's, using advanced imaging techniques in mice to find ways to support memory and brain health in older adults.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11081773 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of microglia, a type of brain cell, in maintaining cognitive function as people age and in the context of Alzheimer's disease. The project aims to integrate various data sources, including brain imaging and postmortem analysis, to explore how these cells contribute to cognitive resilience. By using advanced imaging techniques, researchers will study microglial behavior in mouse models of Alzheimer's, which may provide insights into how to protect memory and cognitive abilities in aging individuals. The findings could lead to new strategies for enhancing brain health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those showing early signs of cognitive decline or at risk for Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those who are not experiencing any cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help preserve cognitive function in aging individuals and those affected by Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Nguyen, Aivi Thanh — Mayo Clinic Rochester
- Study coordinator: Nguyen, Aivi Thanh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.