Investigating how different tau proteins affect brain function in Alzheimer's disease
Project 3: Roles of Tau Levels, Sequence and Interactors in Neural Network Dysfunction of Alzheimer's Disease
This study is looking at how tau proteins affect brain health in people with Alzheimer's disease by using special mouse models, and it aims to find new ways to help improve treatments for those living with the condition.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10897930 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of tau proteins in Alzheimer's disease and how they contribute to brain dysfunction. By creating new mouse models that mimic human conditions, researchers will study various forms of tau, including those that increase the risk of Alzheimer's. The goal is to analyze how these tau proteins interact with other factors, such as amyloid-beta and apolipoprotein E4, to better understand their impact on neuronal health. This comprehensive approach aims to uncover new insights that could lead to improved treatments for Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a genetic predisposition to Alzheimer's disease, particularly those carrying the APOE e4 allele.
Not a fit: Patients with Alzheimer's disease who do not have the APOE e4 allele or those with other unrelated forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that better target the underlying mechanisms of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding tau's role in neurodegenerative diseases, but this specific approach using new mouse models is relatively novel.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Mucke, Lennart — J. David Gladstone Institutes
- Study coordinator: Mucke, Lennart
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.