Investigating how different serotonin receptor variants affect behavior and health.
Official title: Trafficking properties of the serotonin receptor variants
Funded at University of California at Davis · NIH-10894153 · Data updated 2026-11-12
This study is looking at how different types of serotonin receptors in our brains affect behaviors and conditions like depression, ADHD, and bipolar disorder, with the goal of helping patients understand how serotonin influences their treatment and overall well-being.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $190,518 |
| NIH project number | 5R21DA058216-02 |
| Project ID | NIH-10894153 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals aged 21 and older who are experiencing mood disorders, ADHD, or related conditions.
✕Less likely to help
Patients with conditions unrelated to serotonin signaling or those under 21 years old may not benefit from this research.
What this research studies
This research explores the role of serotonin, a key neurotransmitter, in various human behaviors and physiological functions. It focuses on how different variants of serotonin receptors influence conditions such as depression, ADHD, and bipolar disorder. By examining the signaling pathways activated by these receptors, the study aims to uncover the complex mechanisms behind the effectiveness of common antidepressants. Patients may benefit from a better understanding of how serotonin impacts their conditions and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for mood and behavioral disorders by targeting specific serotonin receptor variants.
How similar studies have gone: Previous research has shown promising results in understanding serotonin's role in mood disorders, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Whistler, Jennifer L — University of California at Davis
- Study coordinator: Whistler, Jennifer L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.