Investigating how different proteins affect brain synapses and their function
Molecular mechanisms of excitatory postsynaptic diversity
This study is looking at how certain proteins in the brain affect the connections between nerve cells, which could help us understand more about how our brains work and why some people experience anxiety and depression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project ID | NIH-11000803 on NIH RePORTER |
What this research studies
This research explores the unique patterns of connectivity between neurons and how the strength of these connections is influenced by specific proteins involved in synaptic function. By examining the role of neuron-specific genes and their impact on AMPA receptors, the study aims to understand the molecular mechanisms that underlie synaptic plasticity and cognitive functions. The research utilizes cultured cells and acute brain slice preparations to assess how disruptions in these proteins affect synaptic activity and behavior. Patients may benefit from insights gained into the biological basis of conditions like anxiety and depression.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit would include individuals experiencing cognitive deficits or mood disorders such as anxiety and depression.
Not a fit: Patients with neurological conditions unrelated to synaptic function or those not experiencing cognitive or mood-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cognitive and mood disorders.
How similar studies have performed: Previous research has shown promising results in understanding synaptic mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Albuquerque, United States
- University of New Mexico Health Scis Ctr — Albuquerque, United States (Active)
Researchers
- Principal investigator: Weick, Jason P — University of New Mexico Health Scis Ctr
- Study coordinator: Weick, Jason P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.