Investigating how different pancreatic cells communicate in diabetes
Using ex vivo, in vivo models and patient mutations to interrogate pancreatic exocrine-endocrine cross talk
This study is looking at how different cells in the pancreas talk to each other, especially how they affect the insulin-producing cells in people with Type 1 diabetes, to find new ways to help improve diabetes treatment.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10891644 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between various pancreatic cells, particularly how acinar and duct cells communicate with insulin-secreting beta cells in the context of Type 1 diabetes. By using both laboratory models and patient-derived mutations, the study aims to uncover the mechanisms that lead to the loss of beta cell function. The research will analyze the effects of secretions from acinar and duct cells on human islet and beta cells, which could reveal new therapeutic targets for diabetes treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults diagnosed with Type 1 diabetes who may have specific genetic mutations affecting pancreatic cell function.
Not a fit: Patients with Type 2 diabetes or those without any pancreatic cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Type 1 diabetes and its associated complications.
How similar studies have performed: Previous research has shown promise in understanding pancreatic cell interactions, but this specific approach is relatively novel and aims to deepen existing knowledge.
Where this research is happening
Boston, United States
- Joslin Diabetes Center — Boston, United States (Active)
Researchers
- Principal investigator: Kulkarni, Rohit N. — Joslin Diabetes Center
- Study coordinator: Kulkarni, Rohit N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.