Investigating how different mutations in the KRAS gene affect colorectal cancer
Mouse models of Kras-mutant colorectal cancer
This study is looking at how changes in the KRAS gene affect the growth and treatment of colorectal cancer, using special lab models to help find better ways to treat patients with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10880416 on NIH RePORTER |
What this research studies
This research focuses on colorectal cancer, particularly how mutations in the KRAS gene influence the disease's progression and response to treatment. By using advanced models, including human and mouse organoids, the study aims to understand the varying effects of different KRAS mutations on cancer development and treatment resistance. The researchers will explore whether these mutations lead to distinct behaviors in cancer growth and how they interact with other genes. This could provide insights into more effective treatment strategies for patients with KRAS-mutant colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer that has KRAS mutations.
Not a fit: Patients with colorectal cancer that does not involve KRAS mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that specifically address the challenges posed by KRAS mutations in colorectal cancer.
How similar studies have performed: While there has been significant research into KRAS mutations in cancer, this specific approach using organoid models to explore allele-specific behaviors is relatively novel.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Haigis, Kevin — Dana-Farber Cancer Inst
- Study coordinator: Haigis, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.