Investigating how different forms of a protein affect brain function in Alzheimer's disease
Project 2: Co-pathogenic Interactions between ApoE Isoforms and Abeta in Neural Network Dysfunction of Alzheimer's Disease
This study is looking at how certain proteins related to Alzheimer's disease work together and affect brain function, using special mouse models to help find better treatments that could benefit patients in the future.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10897926 on NIH RePORTER |
What this research studies
This research explores the complex interactions between amyloid beta, apoE isoforms, and tau proteins in the context of Alzheimer's disease. Using advanced mouse models that mimic both late-onset and familial Alzheimer's, the study aims to understand how these proteins contribute to neural dysfunction. By examining these interactions at physiological levels, the research seeks to uncover new insights into the mechanisms of Alzheimer's disease, which could lead to more effective treatments. Patients may benefit from a deeper understanding of the disease's pathology and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to Alzheimer's disease, particularly those carrying the APOE ε4 allele.
Not a fit: Patients with non-Alzheimer's forms of dementia or those without genetic risk factors for Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating Alzheimer's disease.
How similar studies have performed: Previous research has shown that understanding the interactions of amyloid beta and tau proteins can lead to significant advancements in Alzheimer's treatment, indicating that this approach has potential for success.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Palop, Jorge J — J. David Gladstone Institutes
- Study coordinator: Palop, Jorge J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.