Investigating how different forms of a protein affect autoantibody production in autoimmune disease.
Official title: Foxp3 isoform expression and regulation of autoantibody production
Funded at Benaroya Research Inst at Virginia Mason · NIH-11040706 · Data updated 2026-11-12
This study is looking at how different versions of a specific protein might affect the production of autoantibodies in people with Systemic Lupus Erythematosus (SLE), using mouse models to see how outside factors can cause flare-ups, with the goal of finding new ways to help manage or prevent symptoms for those living with SLE.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | November 19, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $709,019 |
| NIH project number | 1R01AI188364-01 |
| Project ID | NIH-11040706 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Systemic Lupus Erythematosus or those with a family history of autoimmune diseases.
✕Less likely to help
Patients with autoimmune diseases other than SLE or those without any autoimmune conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of Foxp3 isoforms in the regulation of autoantibody production, particularly in the context of Systemic Lupus Erythematosus (SLE), an autoimmune disease. By utilizing mouse models that mimic SLE, the study aims to explore how environmental factors can trigger disease flares in patients with latent SLE. The research will analyze gene expression and the immune response to identify potential therapeutic targets that could help manage or prevent SLE symptoms.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating autoimmune diseases like SLE by targeting specific immune responses.
How similar studies have gone: Previous research has shown success in using animal models to study autoimmune diseases, but this specific approach focusing on Foxp3 isoforms is relatively novel.
Where this research is happening
-
Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Ziegler, Steven F — Benaroya Research Inst at Virginia Mason
- Study coordinator: Ziegler, Steven F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.