Investigating how different forms of a liver protein affect metabolism.
Balance between HNF4a isoforms in the carbohydrate-lipid metabolic switch
This study is looking at how two types of a protein called HNF4α affect how the liver handles sugars and fats, which could help us understand more about metabolism and related health issues, using mice to see how these proteins work throughout the day.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-10885033 on NIH RePORTER |
What this research studies
This research explores the roles of two forms of the Hepatocyte Nuclear Factor 4α (HNF4α) protein in regulating how the liver processes carbohydrates and fats. By examining how these protein forms interact with enzymes that sense energy levels in the body, the study aims to understand their impact on metabolic functions such as gluconeogenesis and ketogenesis. The research involves using mouse models to observe how changes in these proteins influence metabolism throughout the day, potentially revealing new insights into metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be experiencing metabolic issues or conditions related to carbohydrate and lipid metabolism.
Not a fit: Patients with metabolic conditions unrelated to the functions of HNF4α or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic disorders like diabetes and obesity.
How similar studies have performed: Previous research has shown that understanding the roles of different protein isoforms can lead to significant advancements in metabolic health, suggesting this approach has potential for success.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Sladek, Frances M. — University of California Riverside
- Study coordinator: Sladek, Frances M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.