Investigating how different forms of a hormone affect ovarian function as women age
FSH Glycoforms and Ovarian Signaling Pathways
This study is looking at how different forms of a hormone called follicle-stimulating hormone (FSH) change as women age and how these changes might affect their ovaries, using mice to help understand the details.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11059170 on NIH RePORTER |
What this research studies
This research focuses on understanding how variations of follicle-stimulating hormone (FSH) influence ovarian signaling pathways, particularly in relation to aging. The study examines how FSH glycoforms, which are different versions of the hormone, change with age and how these changes affect ovarian function. By using genetically engineered mice and in vitro techniques, the researchers aim to uncover the specific mechanisms by which these hormone variants interact with ovarian cells. This could provide insights into the biological processes that occur in the ovaries of aging women.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing age-related changes in ovarian function, particularly those who are peri- or post-menopausal.
Not a fit: Patients who are pre-menopausal or have no age-related ovarian issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for age-related fertility issues and better understanding of ovarian health in post-menopausal women.
How similar studies have performed: Previous research has shown that hormonal variations can significantly impact ovarian function, suggesting that this approach may yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Kumar, T. Rajendra — University of Colorado Denver
- Study coordinator: Kumar, T. Rajendra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.