Investigating how different forms of a blood-clotting inhibitor affect bleeding and clotting disorders.
Official title: Pre-mRNA Processing and Function of Alternatively Spliced Isoforms of TFPI
Funded at Versiti Wisconsin, INC. · NIH-10828432 · Data updated 2026-11-12
This study is looking at how different forms of a protein called Tissue Factor Pathway Inhibitor (TFPI) help control blood clotting and bleeding, which could lead to better treatments for people with bleeding or clotting disorders like Factor V Leiden.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $116,334 |
| NIH project number | 5K99HL163412-02 |
| Project ID | NIH-10828432 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with bleeding or clotting disorders, particularly those affected by conditions like Factor V Leiden.
✕Less likely to help
Patients who do not have any bleeding or clotting disorders may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of Tissue Factor Pathway Inhibitor (TFPI) and its various isoforms in regulating blood clotting and bleeding disorders. By examining how these isoforms are produced and function, especially during embryonic development and in conditions like Factor V Leiden, the study aims to uncover the mechanisms behind their action. Patients may benefit from insights into how alternative splicing of the TFPI gene affects their specific bleeding or clotting disorders, potentially leading to more targeted treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with bleeding and clotting disorders by providing a better understanding of the underlying mechanisms.
How similar studies have gone: Other research has shown promising results in understanding the role of alternative splicing in blood coagulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Versiti Wisconsin, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Siebert-Mckenzie, Amy — Versiti Wisconsin, INC.
- Study coordinator: Siebert-Mckenzie, Amy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.