Investigating how different doses of aspirin affect pregnancy outcomes
Official title: Dose based aspirin pharmacokinetics and pharmacodynamics in pregnancy and association with pregnancy outcomes
Funded at Thomas Jefferson University · NIH-11057311 · Data updated 2026-11-12
This study is looking at how different doses of aspirin can help improve pregnancy outcomes for women at high risk, by seeing if it can prevent issues like preeclampsia and preterm birth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 13, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $678,809 |
| NIH project number | 1R01HD112076-01A1 |
| Project ID | NIH-11057311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women with high-risk singleton pregnancies who are less than 16 weeks pregnant.
✕Less likely to help
Patients with low-risk pregnancies or those who are not pregnant may not receive any benefit from this research.
What this research studies
This research focuses on understanding how aspirin, commonly recommended for high-risk pregnancies, impacts pregnancy outcomes. It aims to determine the effectiveness of different doses of aspirin in preventing complications like preeclampsia and preterm birth. Participants will be randomly assigned to receive either 81mg or 162mg of aspirin daily, starting early in their pregnancy and continuing until late gestation. The study will assess how well aspirin works in the body and its relationship to pregnancy outcomes through various tests and analyses.
Why it matters
Potential benefit: If successful, this research could lead to improved aspirin dosing strategies that enhance pregnancy outcomes for high-risk women.
How similar studies have gone: Previous research has shown promising results in using aspirin to improve pregnancy outcomes, but this study aims to refine dosing specifically for high-risk pregnancies.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Boelig, Rupsa Chaudhury — Thomas Jefferson University
- Study coordinator: Boelig, Rupsa Chaudhury
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.