Investigating how different doses of aspirin affect pregnancy outcomes
Dose based aspirin pharmacokinetics and pharmacodynamics in pregnancy and association with pregnancy outcomes
This study is looking at how different doses of aspirin can help improve pregnancy outcomes for women at high risk, by seeing if it can prevent issues like preeclampsia and preterm birth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11057311 on NIH RePORTER |
What this research studies
This research focuses on understanding how aspirin, commonly recommended for high-risk pregnancies, impacts pregnancy outcomes. It aims to determine the effectiveness of different doses of aspirin in preventing complications like preeclampsia and preterm birth. Participants will be randomly assigned to receive either 81mg or 162mg of aspirin daily, starting early in their pregnancy and continuing until late gestation. The study will assess how well aspirin works in the body and its relationship to pregnancy outcomes through various tests and analyses.
Who could benefit from this research
Good fit: Ideal candidates for this research are women with high-risk singleton pregnancies who are less than 16 weeks pregnant.
Not a fit: Patients with low-risk pregnancies or those who are not pregnant may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved aspirin dosing strategies that enhance pregnancy outcomes for high-risk women.
How similar studies have performed: Previous research has shown promising results in using aspirin to improve pregnancy outcomes, but this study aims to refine dosing specifically for high-risk pregnancies.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Boelig, Rupsa Chaudhury — Thomas Jefferson University
- Study coordinator: Boelig, Rupsa Chaudhury
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.