Investigating how different doses and delivery rates of nicotine affect smoking behavior.
IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate
This study is looking at how different amounts and speeds of nicotine delivery affect people's cravings to smoke and their overall smoking habits, so if you're a smoker interested in understanding how nicotine impacts your urges, this research might be for you!
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10690078 on NIH RePORTER |
What this research studies
This research explores the effects of varying doses and delivery rates of nicotine on smoking behavior and urges. By using intravenous nicotine infusion, the study aims to precisely control how quickly nicotine is delivered to participants, allowing researchers to assess its impact on both the potential for abuse and the alleviation of withdrawal symptoms. Participants will receive different rates of nicotine infusion to determine how these factors influence their cravings and overall smoking experience.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult smokers who are interested in understanding their nicotine use and may be seeking help to quit.
Not a fit: Patients who do not smoke or are not interested in quitting smoking may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved tobacco control strategies and better smoking cessation methods.
How similar studies have performed: Previous studies using similar intravenous nicotine delivery methods have shown promising results in understanding nicotine's effects, indicating that this approach has potential for further exploration.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Sofuoglu, Mehmet — Yale University
- Study coordinator: Sofuoglu, Mehmet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.