Investigating how different brain cells respond to using fentanyl and methamphetamine together
Official title: Cell type transcriptional mechanisms of polysubstance choice
Funded at Virginia Commonwealth University · NIH-11086065 · Data updated 2026-11-12
This study is looking at how using fentanyl and methamphetamine together affects brain cells and decision-making, especially when someone starts using these drugs or tries to stop, to help us understand their impact on behavior and brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | July 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $461,523 |
| NIH project number | 5R01DA058958-03 |
| Project ID | NIH-11086065 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of polysubstance use, particularly those using fentanyl and methamphetamine.
✕Less likely to help
Patients who are not using these substances or who have no history of substance use may not benefit from this research.
What this research studies
This research explores the specific molecular mechanisms in brain cells that are affected by the combined use of fentanyl and methamphetamine, particularly during the initiation and withdrawal phases of substance use. By using animal models, the study aims to simulate decision-making behaviors related to drug and food choices, providing insights into how these substances impact behavior and brain function. The researchers will analyze brain tissue to identify changes at the cellular level, focusing on both neuronal and non-neuronal cells in critical brain regions associated with addiction.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for individuals struggling with polysubstance use disorders.
How similar studies have gone: While research on individual substances has been extensive, the specific investigation of the combined effects of fentanyl and methamphetamine on brain mechanisms is relatively novel.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Hamilton, Peter James — Virginia Commonwealth University
- Study coordinator: Hamilton, Peter James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.