Investigating how different brain cell types and organelles change with aging
Cell-type and organelle-specific multi-omics platform for the study of brain aging
This study is looking at how different molecules in the brain interact and change as we get older or develop conditions like Alzheimer's, with the hope that understanding these changes can help improve treatments for brain health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11058427 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between various biomolecules in the brain, such as proteins, lipids, and metabolites, and how these interactions change as we age or develop age-related diseases like Alzheimer's. By developing a multi-omics platform, the researchers aim to analyze these changes at the level of specific cell types and organelles, which could reveal important mechanisms behind brain aging and related disorders. Patients may benefit from insights gained through this research, as it could lead to better understanding and treatment of conditions like Alzheimer's Disease. The approach involves advanced techniques to integrate different types of biological data to provide a comprehensive view of brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing cognitive decline or those at risk for Alzheimer's Disease and Related Dementias.
Not a fit: Patients with early-onset dementia or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for age-related brain disorders, particularly Alzheimer's Disease.
How similar studies have performed: Other research has shown promise in using multi-omics approaches to understand complex diseases, suggesting potential for success in this novel application.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Lipinski, Marta M — University of Maryland Baltimore
- Study coordinator: Lipinski, Marta M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.