Investigating how dietary nitrate affects exercise performance in heart failure patients
The Inorganic Nitrate and eXercise performance in Heart Failure (iNIX-HF): - a phase II clinical trial
This study is looking at how a daily gelcap containing dietary nitrate might help people with heart failure feel stronger and exercise better, so they can enjoy their daily activities more easily.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10897194 on NIH RePORTER |
What this research studies
This research focuses on patients with heart failure with reduced ejection fraction (HFrEF), a condition that significantly limits their ability to exercise and perform daily activities. The study aims to evaluate the effects of dietary inorganic nitrate, administered in a once-a-day oral gelcap, on improving exercise capacity and muscle function in these patients. By conducting a phase II clinical trial, the researchers will assess the safety and effectiveness of this treatment approach, which has shown promise in preliminary studies. Participants will be involved in various assessments to determine how well the treatment works in enhancing their physical performance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure with reduced ejection fraction (HFrEF) who experience limitations in exercise and daily activities.
Not a fit: Patients with heart failure who do not have reduced ejection fraction or those with other significant comorbidities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option to improve exercise performance and quality of life for patients with heart failure.
How similar studies have performed: Preliminary studies have shown that dietary inorganic nitrate can enhance exercise capacity in patients with heart failure, indicating potential success for this approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Peterson, Linda Ruth — Washington University
- Study coordinator: Peterson, Linda Ruth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.