Investigating how diet and gut health affect liver disease and Alzheimer's risk in diverse populations
Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites
This study is looking at how the gut bacteria and diet affect the early stages of non-alcoholic fatty liver disease and liver damage over ten years, especially in people from different backgrounds, to find new ways to prevent and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project ID | NIH-10940527 on NIH RePORTER |
What this research studies
This research examines the early progression of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis over a decade, focusing on how the gut microbiome influences these conditions in relation to diet. It specifically looks at participants from diverse racial and ethnic backgrounds, including Asian Americans, Native Hawaiians, and Whites, to understand their varying susceptibilities to NAFLD and Alzheimer's disease. By analyzing data from a large cohort, the study aims to uncover new risk factors and relationships that could lead to better prevention and treatment strategies for these diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from Asian American, Native Hawaiian, and White backgrounds who are at risk for NAFLD or Alzheimer's disease.
Not a fit: Patients who do not belong to the specified racial or ethnic groups or those without risk factors for NAFLD or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of liver disease and Alzheimer's risk, particularly for diverse populations.
How similar studies have performed: Previous research has indicated significant differences in Alzheimer's risk among various racial and ethnic groups, suggesting that this approach could yield valuable insights.
Where this research is happening
Honolulu, United States
- University of Hawaii at Manoa — Honolulu, United States (Active)
Researchers
- Principal investigator: Lim, Unhee — University of Hawaii at Manoa
- Study coordinator: Lim, Unhee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.