Investigating how diet affects gut bacteria and blood vessel health
Official title: Application of a novel dietary pattern predictive of trimethylamine N-oxide production to examine associations with metabolomic profiles, the gut microbiome, and vascular health
Funded at State University of New York at Buffalo · NIH-10898570 · Data updated 2026-11-12
This study is looking at how what you eat can affect your heart and blood vessel health, especially for post-menopausal women, by seeing how certain foods change the gut bacteria and a substance called TMAO in your body.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $40,683 |
| NIH project number | 5F31HL168805-02 |
| Project ID | NIH-10898570 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are post-menopausal women who are concerned about their cardiovascular health and dietary habits.
✕Less likely to help
Patients who are not post-menopausal or those without concerns related to cardiovascular health may not benefit from this research.
What this research studies
This research explores the relationship between dietary patterns and vascular health, particularly focusing on how certain foods can influence the gut microbiome and the production of a metabolite called trimethylamine N-oxide (TMAO). By analyzing data from post-menopausal women in the Women’s Health Initiative, the study aims to understand how an overall dietary pattern impacts TMAO production and vascular health. The approach includes non-invasive measurements of blood vessel caliber, providing insights into how diet can affect cardiovascular health without the need for invasive procedures.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that improve vascular health and reduce the risk of cardiovascular disease.
How similar studies have gone: Previous research has shown promising results in understanding the impact of diet on gut microbiome and cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Burns, Kaelyn — State University of New York at Buffalo
- Study coordinator: Burns, Kaelyn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.