Investigating how diet affects brain inflammation related to obesity
Assessing the effect of diet on hypothalamic gliosis in humans
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-10897125
This study is looking at how eating high-calorie foods might affect brain inflammation that can impact weight control, and it's open to both adults and kids who want to help us understand more about obesity.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10897125 on ClinicalTrials.gov |
What this research studies
This research aims to explore the relationship between diet and hypothalamic gliosis, a type of brain inflammation that may influence body weight regulation. By conducting a randomized clinical trial, researchers will assess the effects of high-calorie diets on hypothalamic gliosis in both adults and children. Using advanced imaging techniques like MRI, the study seeks to determine whether dietary changes can induce inflammation in the hypothalamus, which is crucial for understanding obesity mechanisms. Participants will be monitored for safety and feasibility throughout the trial.
Who could benefit from this research
Good fit: Ideal candidates include individuals of all ages who are experiencing obesity or related metabolic conditions.
Not a fit: Patients who are not overweight or do not have metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations and interventions for preventing and treating obesity.
How similar studies have performed: Previous research has shown promising results in animal models, but this study aims to provide controlled clinical evidence in humans.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHUR, ELLEN A — UNIVERSITY OF WASHINGTON
- Study coordinator: SCHUR, ELLEN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus