Investigating how diabetes worsens gum disease through a specific protein interaction
The role of CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus in periodontitis
['FUNDING_R21'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10740433
This study is looking at how diabetes can make gum disease worse and is trying to find new ways to help improve gum health for people with diabetes by focusing on a specific molecular interaction.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10740433 on ClinicalTrials.gov |
What this research studies
This research explores the connection between diabetes mellitus and periodontitis, a serious gum disease. It focuses on the CXCL10-CXCR3 axis, a molecular interaction that may exacerbate inflammation and bone loss in patients with uncontrolled diabetes. By studying this relationship, the research aims to identify potential therapeutic strategies that could improve periodontal health in diabetic patients. The approach includes both experimental models and potential interventions targeting the CXCR3 receptor.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with poorly controlled diabetes who are experiencing periodontitis.
Not a fit: Patients with well-controlled diabetes or those without periodontitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve gum health for patients with diabetes.
How similar studies have performed: Previous research has shown promising results in targeting inflammatory pathways in similar conditions, suggesting potential for success in this approach.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PIRIH, FLAVIA — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: PIRIH, FLAVIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.