Investigating how diabetes affects heart disease through lipoproteins
Official title: Project 1. Diabetes, triglyceride-rich lipoproteins, and advanced atherosclerosis
Funded at University of Washington · NIH-10874522 · Data updated 2026-11-12
This study is looking at how diabetes and metabolic syndrome can lead to heart problems, and it’s testing new ways to help people with diabetes lower their risk of heart disease by improving how their bodies handle certain fats.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 15, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $501,372 |
| NIH project number | 5P01HL151328-05 |
| Project ID | NIH-10874522 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with type 1 or type 2 diabetes, as well as those with metabolic syndrome.
✕Less likely to help
Patients without diabetes or metabolic syndrome may not benefit from this research.
What this research studies
This research focuses on understanding how type 1 and type 2 diabetes, as well as metabolic syndrome, contribute to the development of atherosclerosis, a major cause of heart disease. The study explores innovative methods to enhance the clearance of triglyceride-rich lipoproteins in diabetic patients, which are linked to increased cardiovascular risk. Researchers will employ strategies such as inhibiting specific proteins and enhancing liver function to improve lipid metabolism. By examining these approaches, the research aims to identify potential treatments that could reduce heart disease risk in individuals with diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly lower the risk of heart disease in patients with diabetes.
How similar studies have gone: Previous research has shown promise in similar approaches targeting lipid metabolism in diabetes, indicating potential for success.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Bornfeldt, Karin E. — University of Washington
- Study coordinator: Bornfeldt, Karin E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.