Investigating how diabetes affects fat production in the retina
Modulating retinal lipid biogenesis in diabetes for therapeutic effects
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10857189
This study is looking at how diabetes affects the eye's metabolism and causes the production of certain fats that might lead to vision problems, with the goal of finding new ways to prevent or treat diabetic retinopathy for people with diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10857189 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how diabetes alters the metabolism of the retina, particularly how it increases the production of certain fats that may contribute to diabetic retinopathy, a leading cause of blindness. By examining the early metabolic changes in the retina due to high blood sugar levels, the study aims to identify potential therapeutic targets to prevent or treat vision loss. The approach includes genetic manipulation to explore the pathways involved in fat synthesis and their role in retinal health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with diabetes who are at risk of developing diabetic retinopathy.
Not a fit: Patients without diabetes or those who do not have any retinal complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent vision loss in patients with diabetes.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways for treating diabetic complications, suggesting potential for success in this approach.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAJAGOPAL, RITHWICK — WASHINGTON UNIVERSITY
- Study coordinator: RAJAGOPAL, RITHWICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.