Investigating how diabetes affects brain recovery after stroke
Pericyte phenotypic switching in diabetic post-stroke cognitive impairment (PSCI)
This study is looking at how diabetes affects the brain's ability to heal after a stroke, focusing on special brain cells that change when there's an injury, and it aims to find new ways to help people with diabetes recover better after a stroke.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10855709 on NIH RePORTER |
What this research studies
This research explores the impact of diabetes on brain recovery following a stroke, specifically focusing on how certain cells in the brain, called pericytes, change their behavior in response to injury. The study will use diabetic mice to understand the mechanisms behind these changes and how they contribute to cognitive impairments after a stroke. By examining the signaling pathways between blood vessels and pericytes, the research aims to identify potential therapeutic targets to improve recovery outcomes for patients. The findings could lead to new strategies for managing post-stroke cognitive impairment in individuals with diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who have experienced a stroke and are facing cognitive challenges.
Not a fit: Patients who have not had a stroke or do not have diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive impairments in stroke patients with diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the role of pericytes in stroke recovery, indicating that this approach has potential for success.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Alkayed, Nabil J — Oregon Health & Science University
- Study coordinator: Alkayed, Nabil J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.