Investigating how diabetes affects brain protein changes in Alzheimer's disease
Rates of brain acetylome remodeling in a mouse model of diabetes and tauopathy
This study is looking at how diabetes might affect the brain and contribute to Alzheimer's disease by checking how certain proteins change in the brain, especially those linked to memory, using mice to help find new ways to treat Alzheimer's.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeast Ohio Medical University NIH-funded |
| Lab location | 1 site (Rootstown, United States) |
| Project ID | NIH-10807604 on NIH RePORTER |
What this research studies
This research explores the connection between diabetes and Alzheimer's disease by examining how a specific process called acetylation affects brain proteins. Using a mouse model, researchers will analyze changes in protein dynamics in the brain, particularly focusing on areas associated with memory and cognitive function. The study employs advanced mass spectrometry techniques to measure how diabetes influences protein stability and turnover in the context of Alzheimer's. By understanding these mechanisms, the research aims to shed light on potential therapeutic targets for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults with a diagnosis of Alzheimer's disease, especially those who also have type 2 diabetes.
Not a fit: Patients without Alzheimer's disease or those who do not have diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for Alzheimer's disease, particularly for patients with diabetes.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown promising results in understanding the links between metabolic disorders and neurodegenerative diseases.
Where this research is happening
Rootstown, United States
- Northeast Ohio Medical University — Rootstown, United States (Active)
Researchers
- Principal investigator: Kasumov, Takhar — Northeast Ohio Medical University
- Study coordinator: Kasumov, Takhar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.