Investigating how diabetes affects brain protein changes in Alzheimer's disease
Official title: Rates of brain acetylome remodeling in a mouse model of diabetes and tauopathy
Funded at Northeast Ohio Medical University · NIH-10807604 · Data updated 2026-11-12
This study is looking at how diabetes might affect the brain and contribute to Alzheimer's disease by checking how certain proteins change in the brain, especially those linked to memory, using mice to help find new ways to treat Alzheimer's.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeast Ohio Medical University NIH-funded |
| Lab location | 1 site (Rootstown, United States) |
| Project start | September 30, 2023 |
| Project end | September 29, 2025 |
| Funding year | 2023 |
| Award (this year) | $429,000 |
| NIH project number | 1R21AG085590-01 |
| Project ID | NIH-10807604 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults with a diagnosis of Alzheimer's disease, especially those who also have type 2 diabetes.
✕Less likely to help
Patients without Alzheimer's disease or those who do not have diabetes may not benefit from this research.
What this research studies
This research explores the connection between diabetes and Alzheimer's disease by examining how a specific process called acetylation affects brain proteins. Using a mouse model, researchers will analyze changes in protein dynamics in the brain, particularly focusing on areas associated with memory and cognitive function. The study employs advanced mass spectrometry techniques to measure how diabetes influences protein stability and turnover in the context of Alzheimer's. By understanding these mechanisms, the research aims to shed light on potential therapeutic targets for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for Alzheimer's disease, particularly for patients with diabetes.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown promising results in understanding the links between metabolic disorders and neurodegenerative diseases.
Where this research is happening
-
Northeast Ohio Medical University
Rootstown, United States Active
Researchers
- Principal investigator: Kasumov, Takhar — Northeast Ohio Medical University
- Study coordinator: Kasumov, Takhar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.