Investigating how diabetes affects blood vessel function in the heart.
Coronary Endothelial Cell Dysfunction in Diabetes: Role of MFGE8
This study is looking at how diabetes affects the tiny blood vessels in the heart and how a protein called MFGE8 might help keep them healthy, with the goal of finding new treatments for heart problems in people with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11045675 on NIH RePORTER |
What this research studies
This research focuses on understanding how diabetes leads to dysfunction in the endothelial cells of coronary blood vessels, which can contribute to heart disease. The study aims to explore the mechanisms behind this dysfunction and the role of a specific protein called MFGE8, which may help improve blood vessel health. By examining the effects of MFGE8, the researchers hope to develop new treatments for coronary microvascular disease in diabetic patients. The approach includes both laboratory experiments and potential therapeutic applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are experiencing heart-related issues, particularly those with coronary microvascular disease.
Not a fit: Patients without diabetes or those who do not have any cardiovascular complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart health in patients with diabetes.
How similar studies have performed: Previous research has shown promising results in using similar approaches to address endothelial dysfunction and improve cardiovascular health in diabetic patients.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Makino, Ayako — University of Florida
- Study coordinator: Makino, Ayako
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.