Investigating how desmosome proteins contribute to heart disease
Non-junctional roles of desmosome proteins in the pathogenesis of arrhythmogenic cardiomyopathy
['FUNDING_OTHER'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10705361
This study is looking at how certain proteins in heart cells might cause problems in people with arrhythmogenic cardiomyopathy, a serious heart condition, by using special lab-grown heart cells from patients to better understand the disease and find new treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10705361 on ClinicalTrials.gov |
What this research studies
This research explores the role of desmosome proteins in arrhythmogenic cardiomyopathy, a serious heart condition that can lead to sudden death. By using induced pluripotent stem cells (iPSCs) derived from cardiac patients, the researchers aim to create a model that mimics the disease in the lab. This approach allows for a better understanding of the disease mechanisms and the potential development of new therapies. The study focuses on how mutations in desmosome proteins affect heart cell metabolism and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with arrhythmogenic cardiomyopathy or those with a family history of the disease.
Not a fit: Patients without arrhythmogenic cardiomyopathy or related cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for arrhythmogenic cardiomyopathy, improving outcomes for patients with this condition.
How similar studies have performed: Previous research has shown promising results using similar approaches to model cardiac diseases, indicating a potential for success in this area.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, HUEI-SHENG VINCENT — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: CHEN, HUEI-SHENG VINCENT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.