Investigating how depression affects the immune system in people with HIV
Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
This study is looking at how depression affects the immune system and gut health in people living with HIV, and it’s for those who are HIV positive and dealing with depression; by using a special therapy to help, the researchers hope to find ways to improve their overall health and well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-10954305 on NIH RePORTER |
What this research studies
This research explores the relationship between depression and HIV by examining how depression impacts the immune system and gut health in individuals living with HIV. It focuses on the microbiome-gut-brain axis, which connects gut health to brain function and immune response. The study will involve 120 participants who are HIV positive, depressed, and on effective antiretroviral therapy, utilizing Cognitive-Behavioral Therapy for Adherence and Depression to assess changes in their health. By understanding these connections, the research aims to improve treatment outcomes for those affected.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are experiencing depression and are on an integrase strand transfer inhibitor-based antiretroviral therapy with an undetectable viral load.
Not a fit: Patients who are not living with HIV or those who do not have depression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved mental health and immune function in people living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding the connections between mental health and immune function, making this approach both relevant and potentially impactful.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Carrico, Adam Wayne — Florida International University
- Study coordinator: Carrico, Adam Wayne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.