Investigating how dendritic cells affect the immune response in cancer
Official title: Metabolic checkpoint in dendritic cell subsets and adaptive immunity
Funded at St. Jude Children's Research Hospital · NIH-11016907 · Data updated 2026-11-12
This study is looking at how certain immune cells help the body fight cancer, with the hope of finding new ways to boost the immune response for patients battling the disease.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $455,000 |
| NIH project number | 5R37AI105887-12 |
| Project ID | NIH-11016907 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are cancer patients who are seeking innovative therapies to boost their immune response.
✕Less likely to help
Patients with non-cancerous conditions or those who are not currently undergoing cancer treatment may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of dendritic cell subsets in regulating the adaptive immune response, particularly in the context of cancer. By examining how these immune cells interact with cancer cells and influence anti-tumor immunity, the study aims to identify potential metabolic checkpoints that could be targeted for therapeutic benefit. Patients may benefit from insights gained into how their immune systems can be harnessed to fight cancer more effectively. The research employs advanced biochemical assays and algorithms to analyze immune responses and cancer progression.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the body's immune response against cancer.
How similar studies have gone: Previous research has shown promising results in enhancing anti-tumor immunity through similar approaches, indicating a potential for success in this area.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Chi, Hongbo — St. Jude Children's Research Hospital
- Study coordinator: Chi, Hongbo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.