Investigating how DELE1 activates stress response pathways in aging cells
Official title: Structure-function studies of DELE1-mediated activation of the integrated stress response
Funded at Scripps Research Institute, the · NIH-11160772 · Data updated 2026-11-12
This study is looking at how a protein called DELE1 helps our cells handle stress better as we get older, which could lead to new ways to treat age-related diseases like Alzheimer's and Parkinson's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $620,014 |
| NIH project number | 5R01AG088908-02 |
| Project ID | NIH-11160772 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related cognitive decline or neurodegenerative diseases.
✕Less likely to help
Patients with acute stress conditions unrelated to aging or those without any signs of age-related diseases may not benefit from this research.
What this research studies
This research focuses on understanding how a protein called DELE1 activates the Integrated Stress Response (ISR), which is crucial for maintaining protein balance in cells. As we age, our cells struggle to manage this balance, leading to various age-related diseases like Alzheimer's and Parkinson's. The study will explore the mechanisms by which DELE1 interacts with a specific kinase, Heme-Regulated Inhibitor (HRI), to help cells respond to stress. By examining these cellular pathways, the research aims to uncover potential therapeutic targets for improving proteostasis in aging individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cellular stress responses and improve outcomes for patients with age-related diseases.
How similar studies have gone: Previous research has shown promising results in understanding stress response pathways, indicating that this approach could yield valuable insights.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Lander, Gabriel C — Scripps Research Institute, the
- Study coordinator: Lander, Gabriel C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.