Investigating how defective lipoylation affects heart metabolism and failure.
Official title: Using defective lipoylation as a window into cardiac fuel consumption and failure.
Funded at Ut Southwestern Medical Center · NIH-10901702 · Data updated 2026-11-12
This study is looking at how problems with a nutrient called lipoic acid affect heart function in people with heart failure, especially those born with certain metabolic issues, to find out more about how these changes happen and what new treatments might help.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $77,284 |
| NIH project number | 1F32HL174084-01 |
| Project ID | NIH-10901702 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with diagnosed heart failure or metabolic disorders related to lipoic acid deficiencies.
✕Less likely to help
Patients without heart failure or those not affected by metabolic disorders may not benefit from this research.
What this research studies
This research explores the relationship between cardiac metabolism and heart failure, focusing on how defects in lipoic acid synthesis impact heart function. By studying patients with inborn errors of metabolism, particularly those with lipoic acid deficiencies, the research aims to uncover the mechanisms that lead to metabolic changes in heart cells. The project utilizes patient samples and clinical data to analyze how these metabolic shifts contribute to heart failure, potentially leading to new insights into treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for heart failure, particularly in patients with metabolic disorders.
How similar studies have gone: Previous research has shown promise in understanding metabolic diseases through similar approaches, indicating potential for success in this area.
Where this research is happening
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Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Tippetts, Trevor Stanley — Ut Southwestern Medical Center
- Study coordinator: Tippetts, Trevor Stanley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.