Investigating how deep brain stimulation affects memory and motor function in Rett syndrome mice
Official title: Studying the effects and mechanisms of deep brain stimulation in Rett syndrome mice
Funded at Baylor College of Medicine · NIH-10900594 · Data updated 2026-11-12
This study is looking at how deep brain stimulation might help mice with Rett syndrome by encouraging new brain cell growth and improving their memory and movement skills, which could lead to new treatments for this condition and others like it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2018 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $368,420 |
| NIH project number | 5R01NS100738-07 |
| Project ID | NIH-10900594 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Rett syndrome, particularly children and young adults.
✕Less likely to help
Patients with conditions unrelated to neurodevelopmental disorders or those who do not have Rett syndrome may not benefit from this research.
What this research studies
This research explores the effects of deep brain stimulation (DBS) on mice with Rett syndrome, a severe neurodevelopmental disorder. The study aims to understand how DBS can stimulate the growth of new neurons in the brain and improve memory and motor functions. By applying DBS over a two-week period, researchers will examine the relationship between neurogenesis and memory enhancement, as well as the effects of DBS on motor skills. This research could provide insights into potential therapeutic approaches for Rett syndrome and similar conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve cognitive and motor functions in patients with Rett syndrome.
How similar studies have gone: Previous studies have shown promising results with deep brain stimulation in other neurodevelopmental and neuropsychiatric disorders, suggesting potential for success in this area as well.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Tang, Jianrong — Baylor College of Medicine
- Study coordinator: Tang, Jianrong
Related research
Other NIH-funded projects on the same topics.
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Deep brain stimulation for Rett syndrome
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Cerebellar Deep Brain Stimulation for Spinocerebellar Ataxias
A preliminary clinical trial will test delivering electrical stimulation to the cerebellum in people with spinocerebellar ataxia to see if it improves balance and coordination.
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Improving deep brain stimulation with MRI and AI
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A study in Rett syndrome explores whether tweaking a brain cholesterol enzyme called CYP46A1 could help with the disease by affecting brain pathways involved in Rett.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.