Investigating how deep brain stimulation affects memory and motor function in Rett syndrome mice
Studying the effects and mechanisms of deep brain stimulation in Rett syndrome mice
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10900594
This study is looking at how deep brain stimulation might help mice with Rett syndrome by encouraging new brain cell growth and improving their memory and movement skills, which could lead to new treatments for this condition and others like it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10900594 on ClinicalTrials.gov |
What this research studies
This research explores the effects of deep brain stimulation (DBS) on mice with Rett syndrome, a severe neurodevelopmental disorder. The study aims to understand how DBS can stimulate the growth of new neurons in the brain and improve memory and motor functions. By applying DBS over a two-week period, researchers will examine the relationship between neurogenesis and memory enhancement, as well as the effects of DBS on motor skills. This research could provide insights into potential therapeutic approaches for Rett syndrome and similar conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Rett syndrome, particularly children and young adults.
Not a fit: Patients with conditions unrelated to neurodevelopmental disorders or those who do not have Rett syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve cognitive and motor functions in patients with Rett syndrome.
How similar studies have performed: Previous studies have shown promising results with deep brain stimulation in other neurodevelopmental and neuropsychiatric disorders, suggesting potential for success in this area as well.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TANG, JIANRONG — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: TANG, JIANRONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome