Investigating how deep brain stimulation affects cognitive control in macaques
Modeling circuit-specific psychiatric deep brain stimulation and its cognitive effects in macaques
This study is looking at how deep brain stimulation can help improve thinking and decision-making in macaques, which are similar to humans, to find better treatments for mental health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10922793 on NIH RePORTER |
What this research studies
This research explores the effects of deep brain stimulation (DBS) on cognitive control in macaques, a non-human primate model that closely resembles human brain function. By targeting specific brain circuits, the study aims to understand how DBS can reverse dysfunctions associated with mental disorders. The approach involves detailed animal studies to refine stimulation strategies, which could lead to more effective treatments for psychiatric conditions. The research focuses on the lateral prefrontal cortex, a brain region critical for cognitive regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with psychiatric disorders that may benefit from advanced neurostimulation therapies.
Not a fit: Patients who do not have psychiatric disorders or those who are not candidates for deep brain stimulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved deep brain stimulation techniques that enhance cognitive control and treat mental illnesses more effectively.
How similar studies have performed: Previous studies using non-human primates have shown promising results in understanding deep brain stimulation for movement disorders, indicating potential for success in this novel application.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Widge, Alik S. — University of Minnesota
- Study coordinator: Widge, Alik S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.