Investigating how deep brain stimulation affects brain circuits and cognitive functions.
Circuit and Cognitive Mechanisms of Striatal Deep Brain Stimulation
This study is looking at how deep brain stimulation can help improve thinking skills in people with mental illness by exploring how it works in animal models, so we can make this treatment even better for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10700515 on NIH RePORTER |
What this research studies
This research explores the mechanisms behind deep brain stimulation (DBS) as a treatment for mental illness, focusing on how it can improve cognitive functions such as executive control. By using animal models, the study aims to understand the specific brain circuits involved in DBS and how they relate to symptom improvement in patients. The researchers will conduct experiments to map the effects of stimulation on brain activity and behavior, providing insights that could enhance the effectiveness of DBS in clinical settings. This approach seeks to bridge the gap between animal studies and human applications, ultimately aiming to refine treatment protocols for better patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from mental illnesses that may benefit from deep brain stimulation, particularly those with cognitive impairments.
Not a fit: Patients who do not have mental health disorders or cognitive dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective deep brain stimulation treatments for mental health disorders, improving cognitive functions and overall quality of life for patients.
How similar studies have performed: Previous research has shown promising results in using deep brain stimulation for mental health treatment, indicating that this approach has potential for success.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Widge, Alik S. — University of Minnesota
- Study coordinator: Widge, Alik S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.