Investigating how DAP5 affects breast cancer spread
DAP5-dependent translational control and breast cancer metastasis
This study is looking at a special protein complex that might help breast cancer spread, and by understanding how it works, researchers hope to find new ways to stop cancer from invading other parts of the body, which could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10772083 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein complex, DAP5/eIF3d, in the process of breast cancer metastasis. By using various models, including mouse models and human cancer cell lines, the researchers aim to uncover how this complex influences tumor growth and the ability of cancer cells to invade other tissues. The study will explore the mechanisms behind selective mRNA translation that may contribute to the aggressiveness of breast cancer. Patients may benefit from insights that could lead to new therapeutic targets for preventing cancer spread.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those with aggressive or metastatic forms of the disease.
Not a fit: Patients with non-cancerous conditions or those with early-stage breast cancer that has not metastasized may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the mechanisms of breast cancer metastasis.
How similar studies have performed: Other research has shown promising results in targeting translational control mechanisms in cancer, suggesting that this approach may yield significant insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Schneider, Robert Jay — New York University School of Medicine
- Study coordinator: Schneider, Robert Jay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.