Investigating how damaged DNA forms and its effects
How Damaged DNA Forms, and its Subsequent Chemistry: Fundamental Studies and Applications
This study is looking into how DNA gets damaged and what happens because of that, with the goal of finding new ways to help treat cancer and other diseases related to DNA problems, so patients can have better treatment options in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10845596 on NIH RePORTER |
What this research studies
This research explores the fundamental mechanisms of DNA damage and its biochemical consequences. By utilizing techniques from organic chemistry, biochemistry, and molecular biology, the team aims to uncover new pathways of DNA damage and develop innovative tools such as enzyme inhibitors and radiosensitizing agents. Patients may benefit from advancements in understanding DNA damage, which could lead to improved treatments for cancers and other diseases related to DNA integrity.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with cancers or genetic disorders related to DNA damage.
Not a fit: Patients with conditions unrelated to DNA damage or those not seeking experimental treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for cancer and other diseases caused by DNA damage.
How similar studies have performed: Previous research has shown promise in understanding DNA damage mechanisms and developing related therapies, indicating a potential for success in this area.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Greenberg, Marc M — Johns Hopkins University
- Study coordinator: Greenberg, Marc M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.