Investigating how cytoplasmic chromatin fragments contribute to liver cancer during aging
Project 2: Cytoplasmic chromatin fragments (CCF) as a driver of liver cancer and target for intervention during aging
This study is looking at how tiny pieces of DNA in liver cells might contribute to liver cancer as we get older, and it hopes to find new ways to prevent or treat this type of cancer that could help patients in the future.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10908396 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of cytoplasmic chromatin fragments (CCF) in the development of liver cancer, particularly hepatocellular carcinoma (HCC), as people age. It explores how aging-related changes in cells can lead to the accumulation of these fragments, which may trigger inflammation and promote cancer progression. By examining the mechanisms behind CCF and their effects on liver health, the research aims to identify potential new therapies and preventive strategies for liver cancer. Patients may benefit from insights that could lead to innovative treatments targeting these cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults at risk for liver cancer or those diagnosed with non-alcoholic fatty liver disease (NAFLD).
Not a fit: Patients with liver cancer unrelated to aging or those without any liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or treat liver cancer in aging populations.
How similar studies have performed: Other research has shown promising results in targeting cellular aging processes to improve health outcomes, suggesting potential success for this approach.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Adams, Peter D. — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Adams, Peter D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.