Investigating how cytomegalovirus affects the retina
Official title: Bottom-up and top-down computational modeling approaches to study CMV retinitis
Funded at Medical College of Wisconsin · NIH-10915436 · Data updated 2026-11-12
This study is looking at how the human cytomegalovirus affects the eyes, especially for people with weakened immune systems, to find better ways to prevent vision loss and improve treatment options.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | July 26, 2023 |
| Project end | July 25, 2027 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30AI179084-02 |
| Project ID | NIH-10915436 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are immunocompromised individuals, particularly those at risk for CMV retinitis.
✕Less likely to help
Patients who are not immunocompromised or do not have a history of CMV infection may not benefit from this research.
What this research studies
This research focuses on understanding the impact of human cytomegalovirus (HCMV) on the retina, particularly in patients with weakened immune systems. It employs advanced computational modeling techniques to analyze the virus's replication process and its effects on retinal cells. By studying how HCMV can lead to conditions like CMV retinitis, the research aims to uncover new therapeutic strategies to prevent vision loss. Patients may benefit from improved diagnostic and treatment options as a result of this work.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for vision loss caused by CMV retinitis.
How similar studies have gone: While computational modeling has been applied in some viral studies, this specific approach to CMV retinitis is relatively novel and has not been extensively tested.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Monti, Christopher E — Medical College of Wisconsin
- Study coordinator: Monti, Christopher E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.