Investigating how cytokines affect pancreatic beta-cell function in diabetes
GRASP55 Regulates Pancreatic Beta-cell Golgi Structure and Function During Cytokine Stress
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF IOWA · NIH-11076621
This study is looking at how certain proteins in the body can affect the insulin-producing cells in the pancreas, which is important for people with Type 1 Diabetes, and aims to find ways to help protect these cells from damage during the disease.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11076621 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the impact of proinflammatory cytokines on the structure and function of pancreatic beta-cells, which are crucial for insulin production. The study aims to explore how these cytokines disrupt the Golgi apparatus within beta-cells, leading to early defects in their ability to secrete insulin. By examining the role of a specific protein, GRASP55, the researchers hope to uncover mechanisms that contribute to the progression of Type 1 Diabetes. Patients may benefit from insights that could lead to new therapeutic strategies to protect beta-cell function during autoimmune attacks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Type 1 Diabetes or those at risk of developing the condition due to autoimmune factors.
Not a fit: Patients with Type 2 Diabetes or other forms of diabetes unrelated to autoimmune processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that preserve pancreatic beta-cell function in patients with Type 1 Diabetes.
How similar studies have performed: Other research has shown promising results in understanding cytokine effects on beta-cell function, suggesting that this approach could yield valuable insights.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BLOM, SANDRA — UNIVERSITY OF IOWA
- Study coordinator: BLOM, SANDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus, Brittle Diabetes Mellitus, cell injury