Investigating how cysteine oxidation affects cellular processes
Developing chemical-proteomic tools to investigate cysteine oxidation
This study is looking at how certain molecules called reactive oxygen species affect important proteins in our cells, especially in diseases like cancer, and it aims to develop new tools to see these changes happening in real-time to better understand how they impact health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston College NIH-funded |
| Lab location | 1 site (Chestnut Hill, United States) |
| Project ID | NIH-10756468 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of reactive oxygen species (ROS) in cellular signaling, particularly how they affect cysteine thiols in various diseases, including cancer. By developing advanced chemical-proteomic tools, the researchers aim to track and analyze cysteine oxidation events in real-time and in specific cellular locations. The study will utilize innovative techniques, such as light-activated probes and proximity biotinylation, to provide detailed insights into how these oxidative modifications influence cellular functions and disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers or age-related degenerative diseases that may involve dysregulated redox homeostasis.
Not a fit: Patients with conditions unrelated to oxidative stress or cysteine metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing diseases associated with oxidative stress, such as cancer.
How similar studies have performed: Previous research has shown promising results in understanding oxidative stress and its implications in various diseases, indicating that this approach has potential for significant findings.
Where this research is happening
Chestnut Hill, United States
- Boston College — Chestnut Hill, United States (Active)
Researchers
- Principal investigator: Weerapana, Eranthie — Boston College
- Study coordinator: Weerapana, Eranthie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.